Martino was born in Philadelphia, Pennsylvania on April 13, 1902. At the age of twenty-three he had two paintings accepted in the Pennsylvania Academy for the Fine Arts Annual Exhibition. He had a long career and would paint for the next fifty years.

Early in his career he decided to concentrate on landscapes, and painted along the Darby Creek and on the Delaware River above New Hope. These landscapes were painted outdoors with the direct impressionistic brushwork of Redfield and Schofield. Later he did countless views of Manayunk and East coast subjects, gradually developing his personal style of solid, simplified compositions in rich tone and color.

Antonio Martino died in Thousand Oaks, California on September 3, 1988.